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Resistance Exercise Training May Improve Muscle Strength in Patients With Barth Syndrome

Posted on February 27, 2020
Resistance Exercise Training May Improve Muscle Strength in Patients With Barth Syndrome

Resistance exercise training promotes increased muscle strength and appears safe and well-tolerated by patients with Barth syndrome, according to a pilot study. The study assessed the overall skeletal muscle strength/performance of 9 adolescents and young adults with Barth syndrome, which were compared with those of age- and activity-matched controls. Among the Bath syndrome patients, 3 proceeded to a supervised 12-week resistance exercise training program, which involved 3 weekly sessions lasting 60 minutes each.

Compared with controls, patients with Barth syndrome demonstrated the following:

  • Lower strength and lean muscle mass (all P<.05)
  • Diminished lower extremity, upper extremity, thoracic spine, lumbar spine, and pelvic bone mineral density (all P<.05);
  • Reduced exercise capacity (P<.001).

Following the 12-week resistance training program, the patients with Barth syndrome showed significantly increased upper and lower extremity muscle strength compared with baseline (P<.05). No adverse events were identified and the exercise regimen was well-tolerated and attended.

Read more here.

Reference

Bittel AJ, Bohnert KL, Reeds DN, et al. Reduced muscle strength in Barth syndrome may be improved by resistance exercise training: a pilot study. JIMD Reports. 2018;41:63-72. doi:10.1007/8904_2018_102.

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