Although the majority of patients with sickle cell disease (SCD) who underwent bone marrow transplantation (BMT) remained vaso‐occlusive crises (VOCs)‐free over 2 years, transplant‐related complications remained high, according to a study.
In this cohort study of 204 patients with SCD who underwent BMT, US Medicaid claims data were used to analyze the rates of VOCs and other complications after BMT.
Over a median follow-up of 2.1 years, the overall VOC rate was 0.99 per person‐year, with 67.6% (138/204) of patients remaining VOCs-free. The mortality rate was 1.7 per 100 person‐years. Transplant‐related complications occurred in 55.4% (113/204) of patients with an incidence rate of 38.2 per 100 person‐years and 23% of patients had GvHD with an incidence rate of 8.0 per 100 person‐years.
The authors concluded that “this highlights a continuing unmet need for alternative curative interventions in SCD.”
Mahesri M, Schneeweiss S, Globe D, et al. Clinical outcomes following bone marrow transplantation in patients with sickle cell disease: A cohort study of US Medicaid enrollees. Eur J Haematol. 2020; https://doi.org/10.1111/ejh.13546.