Infectious Diseases
Journal Scan

Journal Brief: Top 5 Infectious Disease Articles

Posted on September 7, 2020

Adjuvanted trivalent influenza vaccine effective in nursing home residents
Adjuvanted trivalent influenza vaccine was more effective in preventing all-cause and pneumonia and influenza hospitalization than non-adjuvanted trivalent influenza vaccine in nursing home residents. The study took place during an A/H3N2 predominant season when non-adjuvanted trivalent influenza vaccine was considered relatively ineffective.

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Reference
McConeghy KW, Davidson HE, Canaday DH, et al. Cluster-randomized trial of adjuvanted vs. non-adjuvanted trivalent influenza vaccine in 823 U.S. nursing homes.Clin Infect Dis. 2020;ciaa1233. https://doi.org/10.1093/cid/ciaa1233

HIV infections linked to higher rate of recurrent acute coronary syndrome
People living with HIV had a higher rate of recurrent acute coronary syndrome compared with HIV‐uninfected patients, although the risk of major adverse cardiac and cerebrovascular events was not statistically significant between the groups.

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Reference
Boccara F, Murielle MK, Potard V, et al. HIV infection and long‐term residual cardiovascular risk after acute coronary syndrome. JAHA. 2020;9(17):https://doi.org/10.1161/JAHA.119.017578.

HPV screening in women living with HIV
This study sought to better understand primary human papillomavirus (HPV) screening in women living with HIV. Researchers found that HPV screening with reflex HPV16/18-genotyping resulted in fewer unnecessary colposcopies and have the potential to be an alternative to concurrent oncogenic human papillomavirus and pap testing in this patient population.

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Reference
Strickler HD, Keller MJ, Hessol NA, et al. Primary HPV and molecular cervical cancer screening in US women living with HIV. Clin Infect Dis. 2020; ciaa1317, https://doi.org/10.1093/cid/ciaa1317.

Hepatic decompensation not eliminated when receiving antiviral therapy for HBV-related cirrhosis
In this post hoc analysis of 2 prospective hepatitis B virus cohorts, hepatic decompensation was found to be uncommon but not completed eliminated in patients receiving antiviral therapy for HBV-related cirrhosis. Approximately 33% of decompensating events were secondary to HCC. Utilizing Baveno VI criteria may identify patients at risk of decompensation.

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Reference
Won Lee H, Yip T CF, Tse YK, et al. Hepatic decompensation in cirrhotic patients receiving antiviral therapy for chronic hepatitis B. Clin Gastroenterol Hepatol. 2020; DOI:https://doi.org/10.1016/j.cgh.2020.08.064