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Journal Scan
Metabolic

Recent-onset diabetes, weight loss increases risk for cancer

Posted on August 13, 2020

Individuals with recent-onset diabetes accompanied by weight loss are at an increased risk for developing pancreatic cancer, according to a study in JAMA Oncology.

This patient population may benefit from early detection strategies.

Of the 112 818 women and 46 207 men included in this cohort study, 1116 incident cases of pancreatic cancers were found.

Participants with recent-onset diabetes had an age-adjusted hazard ratio for pancreatic cancer of 2.97 compared to those with no diabetes. Participants with long-standing diabetes had an age-adjusted hazard ratio of 2.16 compared to those with no diabetes.

A 1- to 4-lb and 5- to 8-lb weight loss was associated with an age-adjusted hazard ratio for pancreatic cancer of 1.25 and 1.92, respectively. Those with recent-onset diabetes who also had a 1 to 8 lb weight loss or more than 8 lb had a substantially increased risk for pancreatic cancer. Recent-onset diabetes and weight loss with a body mass index of less than 25 before weight loss and nonintentional weight loss was associated with higher incidence rates.

Reference
Yuan C, Babic A, Khalaf N, et al. Diabetes, weight change, and pancreatic cancer risk. JAMA Oncol. 2020. doi:10.1001/jamaoncol.2020.2948

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