IV immunoglobulins plus methylprednisolone improves fever course in MIS-C
Children with multisystem inflammatory syndrome in children (MIS-C) treated with intravenous immunoglobulins (IVIG) plus methylprednisolone experience a more favorable fever course than children treated with IVIG alone, according to a study in JAMA.
In this retrospective cohort study of 111 children with MIS-C, 34 children were treated with IVIG and methylprednisolone, 72 were treated with IVIG alone, and 5 children did not receive either treatment. Overall, 9% of patients in the combination group and 51% of patients in the IVIG alone group did not respond to treatment. Treatments with IVIG and methylprednisolone was associated with a lower risk of treatment failure compared to IVIG alone.
Compared with IVIG alone, the combination treatment was also significantly associated with a lower risk of use of second-line therapy, hemodynamic support, acute left ventricular dysfunction occurring after initial therapy, and duration of stay in the pediatric intensive care unit.
Ouldali N, Toubiana J, Antona D, et al. Association of intravenous immunoglobulins plus methylprednisolone vs immunoglobulins alone with course of fever in multisystem inflammatory syndrome in children. JAMA. 2021;doi:10.1001/jama.2021.0694