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High-dose Corticosteroids Improves Odds of Recovery From Bell’s Palsy at 6 Months

Posted on February 27, 2020
High-dose Corticosteroids Improves Odds of Recovery From Bell’s Palsy at 6 Months

Use of high-dose corticosteroids (prednisolone [PSL], ≥100 mg daily) reduces nonrecovery at 6 months in patients with Bell’s palsy compared with use of standard-dose corticosteroids (initial PSL, 50-60 mg), according to a systematic review and meta-analysis that included 8 studies. In the studies, patients on high-dose corticosteroids received doses ranging from 120 mg to 200 mg PSL daily. Compared with standard-dose corticosteroids, high-dose corticosteroids were associated with a significantly decreased nonrecovery at 6 months after the onset of Bell’s palsy (odds ratio 0.42; 95% confidence interval, 0.22-0.80). Based on the findings, the study investigators concluded that “further prospective study is needed to identify an adequate dose of corticosteroids in these patients.”

Read more here.

Reference

Fujiwara T, Namekawa M, Kuriyama A, Tamaki H. High-dose corticosteroids for adult Bell’s palsy: systematic review and meta-analysis. Otol Neurotol. 2019 Jul 8. doi: 10.1097/MAO.0000000000002317.

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