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Oncology
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Combination of Umbralisib and Ublituximab Improves Progression-free Survival in Chronic Lymphocytic Leukemia

Posted on May 5, 2020

The combination of umbralisib plus ublituximab significantly improved progression-free survival (PFS) compared to obinutuzumab plus chlorambucil in patients with previously untreated and relapsed/refractory chronic lymphocytic leukemia (CLL), according to results from the global UNITY-CLL Phase 3 trial.

“It’s extremely gratifying to see positive results for this important trial exploring the combination of umbralisib and ublituximab in patients with both front-line and relapsed/refractory CLL,” said John Gribben, MD, DSc, FRCP, FRCPath, FMed Sci, Professor of Medical Oncology, Barts Cancer Institute, London, UK, and Global Study Chair for the UNITY-CLL study, in a press release. “Today’s outcome marks the first successful Phase 3 trial of a PI3K delta-based regimen in a CLL patient population that included previously untreated patients.” Dr. Gribben continued, “CLL remains incurable and new treatment options are still very much needed, particularly those that provide a differentiated mechanism and safety profile from our currently available treatment options.”

Read the full press release here.

SOURCE: TG Therapeutics

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