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Plumonary and Lung

Cytological Diagnosis May Prevent Invasive Biopsy in Patients With Langerhans Cell Histiocytosis

Posted on February 27, 2020
Cytological Diagnosis May Prevent Invasive Biopsy in Patients With Langerhans Cell Histiocytosis

Langerhans cell histiocytosis (LCH) is difficult to diagnose because it is so rare; however, an assessment of a large cohort of cases identified cytomorphological features that can facilitate a timely diagnosis and potentially avoid the need for an invasive biopsy. The cohort included 47 LCH cases diagnosed using cytological material and fine-needle aspiration (FNA) over a 14-year period (2003-2016). Key cytological findings included the following:

  • Most cytological smears (58%) were moderately to highly cellular and contained abundant Langerhans cells (72%).
  • 38% of smears revealed areas of necrosis and 78% revealed giant cells.
  • Most smears showed mild eosinophilia (61%), sparse lymphocytosis (83%), and mild neutrophilic infiltration (64%).
  • There were 1 to 2 mitoses per 10 high power field in 12 cases (25.5%), with no abnormal mitoses identified.

Read more here.

Reference

Phulware RH, Guleria P, Iyer VK, et al. Cytological diagnosis of Langerhans cell histiocytosis: a series of 47 cases. Cytopathology. 2019 Apr 24. doi: 10.1111/cyt.12709.

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