Histotype, disease-free interval may predict lung metastasis recurrence in STS
Specific histotypes and disease-free interval length may predict lung metastasis recurrence and lung metastasis-specific mortality in patients with soft tissue sarcomas (STS), according to a study.
In this analysis, lung metastasis recurrence (LMR) and lung metastasis-specific mortality (LMSM) was studied in 164 patients with STS lung metastasectomy (LMTS) over the course of 30 years.
The 10- and 15- year LMR cumulative incidence were 0.77 (0.76-0.78). The 10- and 15- year freedom from LMSM incidence were 0.60 [0.51-0.70] and 0.56 [0.47-0.67], respectively.
LMR was predicted by malignant peripheral nerve sheath tumor histotype, a disease-free interval up to 68 months, and lung metastasis size ≥4 mm. LMSM was predicted by myxofibrosarcoma, synovial sarcoma, adjuvant chemotherapy, a disease-free interval between 2-20 months, and a primary tumor size between 3.6 cm and 10 cm.
In patients with a tumor size from ≥20 cm, there was a sharp increase in LMSM.
The authors noted that these findings needed to be confirmed by larger randomized studies.
Tetta C, Rocca M, Salone M, et al. Predictors of lung recurrence and disease-specific mortality after pulmonary metastasectomy for soft tissue sarcoma. Surg Oncol. 2021;37:101532. DOI: 10.1016/j.suronc.2021.101532. Epub ahead of print. PMID: 33639455.