1. Nov 16, 2020

Nomogram predicts overall survival in patients with Ewing sarcoma

A nomogram demonstrated a good ability to predict 3- and 5-year overall survival (OS) in patients with Ewing sarcoma, according to a study.

Researchers gathered demographic and clinic pathological characteristics from the Surveillance, Epidemiology, and End Results (SEER) database. A total of 578 patients were included.

Age, 7th AJCC stage, 7th AJCC T stage, 7th AJCC N stage, 7th AJCC M stage, and metastatic status to lung, liver, and bone were found to be significant factors according to univariate Cox analysis. A multivariate Cox analysis confirmed age, N stage, and bone metastasis were independent variables.

A nomogram was created using the independent variable to predict the 3- and 5-year OS. C-indexes and calibration curves closer to ideal curves showed the accurate predictive ability of this nomogram, the authors concluded.

Zhou Z, Wang J, Fang L, et al. A nomogram for predicting overall survival in patients with Ewing sarcoma: a SEER-based study. BMC Musculoskelet Disord. 2020;12;21(1):737. DOI: 10.1186/s12891-020-03706-3. PMID: 33183244.