PD‐1/PD‐L1 expression differs according to Kaposi sarcoma stage

PD‐1 and PD‐L1 expression patterns differ based on Kaposi sarcoma sage, but is not impacted by clinical variables, according to a study.

In this study, 50 patients with KD who were classified as early or late stage disease, had specimens stained with anti‐PD‐1 and anti‐PD‐L1 antibodies.

In 72.2% and 11.1% of early stage cases and 43.8% and 28.1% of late-stage cases, PD-1 and PD-L1, respectively, were expressed.

PD‐1 expression was significantly higher in the peritumoral area than in the intratumoral area in late stage cases. PD‐1 expression in the intratumoral area was significantly higher at the early stage than at the late stage, whereas PD‐L1 expression in the peritumoral area was significantly higher at the late stage than at the early stage.

Reference

Kim YJ, Jung CJ, Won CH, et al. PD‐1 and PD‐L1 expression in Kaposi sarcoma: A comparative study according to the pathological stage and clinical characteristics. J Cutan Pathol. 2020; https://doi.org/10.1111/cup.13841