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Journal Scan
Sarcoma

What’s the best first-line chemotherapy for advanced soft tissue sarcoma?

Posted on April 20, 2021

Researchers performed a network meta-analysis to compare overall survival (OS), overall response rate (ORR), progression-free survival (PFS), and toxicity after treatment with several different first-line chemotherapy regimens in patients with advanced soft tissue sarcoma. Overall, 28 eligible trials with a total of 6928 patients were included.

In terms of OS, epirubicin plus cisplatin was the best regimen but may have more hematological toxicities than doxorubicin and has only been evaluated in a small trial.

In terms of PFS and ORR, doxorubicin was superior.

The authors concluded that, overall, doxorubicin may be the best regimen for the first-line chemotherapy for patients with advanced soft tissue sarcoma.

Reference
Hua Q, Xu G, Zhao L, et al. Comparison of first line chemotherapy regimens for advanced soft tissue sarcoma: a network meta-analysis. J Chemother. 2021;1-12. doi: 10.1080/1120009X.2021.1913703. Epub ahead of print. PMID: 33870875.

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