Case report highlights TED after COVID-19 vaccine in patient with Graves’ Disease history

In this case report, a 50-year-old woman presented with periorbital swelling and proptosis that had lasted for 2 months and began 3 days after receiving her second COVID-19 vaccination. The patient had a history of Graves’ disease without clinical ophthalmopathy.

A diagnosis of active thyroid eye disease was made after orbital imaging and a negative systemic work-up for other diseases, as well as elevated thyroid-stimulating immunoglobulin.

“The temporal relationship to her vaccination was likely consistent with autoimmune/inflammatory syndrome associated with adjuvants,” the authors wrote.

They concluded that clinicians should make sure patients are aware of the signs and symptoms of thyroid eye disease.

Reference
Rubinstein TJ. Thyroid Eye Disease Following COVID-19 Vaccine in a Patient With a History Graves’ Disease: A Case Report. Ophthalmic Plast Reconstr Surg. 2021 Sep 24. doi: 10.1097/IOP.0000000000002059. Epub ahead of print. PMID: 34570048.